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Whooley Questions: Two-Question Depression Screen

Ask the two Whooley questions. A “yes” to either needs a fuller assessment.

By Dr Amer Sheikh, GP Updated 17 October 2026 Clinical review pending

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What are the Whooley questions?

They are two quick screening questions for depression:

They are recommended by NICE, including in pregnancy and after birth.

Interpretation

AnswerResult
No to bothDepression unlikely
Yes to eitherPositive: assess further, for example with the PHQ-9

Frequently asked questions

What if the Whooley questions are positive?

Do a fuller assessment, using the PHQ-9 and a clinical interview.

Are the Whooley questions used in pregnancy?

Yes. NICE CG192 suggests them at booking and in the postnatal period.

How accurate are the Whooley questions?

They are highly sensitive, so a negative answer to both makes depression unlikely.

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References

  1. Whooley MA, Avins AL, Miranda J, Browner WS. Case-finding instruments for depression. J Gen Intern Med 1997;12(7):439–45.
  2. NICE. Depression in adults: treatment and management. NG222. nice.org.uk/guidance/ng222

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