Mood Disorder Questionnaire (MDQ) for Bipolar Disorder

Screen for bipolar spectrum disorder with the MDQ. All three parts are checked automatically.

By Dr Amer Sheikh, GP Updated 17 October 2026 Clinical review pending

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What is the MDQ?

The Mood Disorder Questionnaire screens for a lifetime history of mania or hypomania. It has 13 symptom questions and two follow-up questions.

When is the MDQ positive?

7 or more of the 13 symptoms, and
several symptoms happened at the same time, and
they caused a moderate or serious problem.

It misses many people with bipolar II. If you are suspicious, ask about hypomania directly. Avoid starting an antidepressant alone until bipolar disorder has been considered (NICE CG185).

Frequently asked questions

What makes the MDQ positive?

7 or more symptoms, occurring together, causing a moderate or serious problem.

Does a negative MDQ rule out bipolar disorder?

No. It often misses bipolar II. Ask about hypomania if concern remains.

What should I do after a positive MDQ?

Refer for specialist assessment if bipolar disorder is suspected (NICE CG185).

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References

Hirschfeld RM, Williams JB, Spitzer RL, et al. Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder Questionnaire. Am J Psychiatry 2000;157(11):1873–5.
NICE. Bipolar disorder: assessment and management. CG185. nice.org.uk/guidance/cg185

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