What is anticholinergic burden?
Many common medicines have anticholinergic effects. Together they can cause confusion, falls, constipation and urinary retention.
The ACB scale scores each medicine 1, 2 or 3. The total gives the burden.
Interpreting the ACB score
| Total | Meaning |
|---|
| 0 | No burden |
| 1–2 | Low burden |
| 3 or more | Clinically relevant: consider deprescribing |
A total of 3 or more is linked with cognitive impairment, falls and higher mortality in older people.
Frequently asked questions
What is a high ACB score?
A total of 3 or more is clinically relevant.
Which medicines have the highest burden?
Examples include amitriptyline, oxybutynin, chlorphenamine and paroxetine, which score 3.
Do ACB lists vary?
Yes. Versions differ. Check unlisted medicines in the full ACB calculator.
References
- Boustani M, Campbell N, Munger S, et al. Impact of anticholinergics on the aging brain. Aging Health 2008;4(3):311–20.
- ACB calculator. acbcalc.com
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